Structure of PDB 6r4h Chain A

Receptor sequence
>6r4hA (length=663) Species: 9606 (Homo sapiens) [Search protein sequence]
CGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWE
ANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGE
PSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTET
IAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGT
RRGSPLLIGVRSEHKLSTDHIPILYRSRVDSTTCLFPVEEKAVEYYFASD
ASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIHPGRAVQTLQMELQQIMK
GNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRR
LILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCF
FLSQSGETADTLMGLRYCKERGALTVGITNTVESSISRETDCGVHINAGP
EIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIK
EVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSE
GILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVV
ICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDV
DFPRNLAKSVTVE
3D structure
PDB6r4h Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
ChainA
Resolution2.244 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L8 R33 W96 N123 G124 E554 K558 E561 H577 K676
Catalytic site (residue number reindexed from 1) L7 R32 W95 N122 G123 E536 K540 E543 H559 K658
Enzyme Commision number 2.6.1.16: glutamine--fructose-6-phosphate transaminase (isomerizing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G6Q A G375 T376 S377 S421 Q422 S423 T426 S474 K558 E561 G357 T358 S359 S403 Q404 S405 T408 S456 K540 E543
BS02 GLU A C2 R95 W96 T98 H108 N123 G124 D148 C1 R94 W95 T97 H107 N122 G123 D147
Gene Ontology
Molecular Function
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0097367 carbohydrate derivative binding
Biological Process
GO:1901135 carbohydrate derivative metabolic process
GO:1901137 carbohydrate derivative biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6r4h, PDBe:6r4h, PDBj:6r4h
PDBsum6r4h
PubMed32019926
UniProtQ06210|GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (Gene Name=GFPT1)

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