Structure of PDB 6r39 Chain A

Receptor sequence
>6r39A (length=327) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNR
GLTVIDVAESLLSLSPDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMD
DVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQ
LYDVTSMFDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDM
GVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFL
AKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQV
KELIEKLRLCSPGFAASVETLWGKTYK
3D structure
PDB6r39 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K47 H98 D103 D107 D175 K212 F251 D255 D256
Catalytic site (residue number reindexed from 1) K47 H91 D96 D100 D153 K175 F214 D218 D219
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BFH A K47 N49 R50 T217 Y218 K361 K47 N49 R50 T180 Y181 K324
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r39, PDBe:6r39, PDBj:6r39
PDBsum6r39
PubMed
UniProtQ86C09

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