Structure of PDB 6r2p Chain A

Receptor sequence

>6r2pA (length=497) Species: 5061 (Aspergillus niger)

AQPAHLCFRSFVEALKVDNDLVEINTPIDPNLEAAAITRRVCETNDKAPL
FNNLIGMKNGLFRILGAPGSLRKSSADRYGRLARHLALPPTASMREILDK
MLSASDMPPIPPTIVPTGPCKENSLDDSEFDLTELPVPLIHKSDGGKYIQ
TYGMHIVQSPDGTWTNWSIARAMVHDKNHLTGLVIPPQHIWQIHQMWKKE
GRSDVPWALAFGVPPAAIMASSMPIPDGVTEAGYVGAMTGSSLELVKCDT
NDLYVPATSEIVLEGTLSISETGPEGPFGEMHGYIFPGDTHLGAKYKVNR
ITYRNNAIMPMSSCGRLTDETHTMIGSLAAAEIRKLCQQNDLPITDAFAP
FESQVTWVALRVDTEKLRAMKTTSEGFRKRVGDVVFNHKAGYTIHRLVLV
GDDIDVYEGKDVLWAFSTRCRPGMDETLFEDVRGFPLIPYMGHGNGPAHR
GGKVVSDALMPTEYTTGRNWEAADFNQSYPEDLKQKVLDNWTKMGFS

3D structure

• PDB: 6r2p Atomic description of an enzyme reaction dependent on reversible 1,3-dipolar cycloaddition
• Chain: A
• Resolution: 1.26 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.102: phenacrylate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FMN	A	N168 S170 I171 A172 R173 Q190 H191 S223 S224 M225 P226 I327 K391	N166 S168 I169 A170 R171 Q188 H189 S221 S222 M223 P224 I325 K389
BS02	MN	A	N168 H191 E233	N166 H189 E231

Gene Ontology

Molecular Function

• GO:0016831 carboxy-lyase activity
• GO:0030145 manganese ion binding
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0009074 aromatic amino acid family catabolic process
• GO:0018966 styrene metabolic process
• GO:0033494 ferulate metabolic process
• GO:0046281 cinnamic acid catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6r2p, PDBe:6r2p, PDBj:6r2p
• PDBsum: 6r2p
• UniProt: A2QHE5|FDC1_ASPNC Ferulic acid decarboxylase 1 (Gene Name=fdc1)