Structure of PDB 6r07 Chain A

Receptor sequence
>6r07A (length=357) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
ASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFR
GMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIM
DGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKD
LLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYK
RIVKYKTTFYTYLLPLVMGLLVSEAAASVEMNLVERVAHLIGEYFQVQDD
VMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGEKD
PAKVAVVKRLYSKANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVA
VVWEKTH
3D structure
PDB6r07 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
ChainA
Resolution1.57 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K48 H93 D98 D102 R107 D170 K207 F246 D250 D251
Catalytic site (residue number reindexed from 1) K47 H92 D97 D101 R106 D169 K206 F245 D249 D250
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3N2 A F210 E236 H240 F209 E235 H239
BS02 3N2 A D151 L155 E236 D150 L154 E235
BS03 ZN A D98 D102 D97 D101
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008299 isoprenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6r07, PDBe:6r07, PDBj:6r07
PDBsum6r07
PubMed
UniProtQ8WS26

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