Structure of PDB 6qzw Chain A

Receptor sequence
>6qzwA (length=833) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKYHKAPHDFMFVKRNDPDGPHSDRIYYL
AMSRENTLFYSEIPKTINRAAVLMLSWKPLLDLYSREEELLRERKRIGTV
GIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNI
RMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDAR
SAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEII
HVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKEL
IQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIP
VEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEI
EFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAI
TSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVT
RLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTK
EFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPT
VLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKF
EGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMA
LMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQ
AEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQER
HSIRVPESGEHYELHLLHYLQENLGSRIAALKV
3D structure
PDB6qzw Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y605 S691 Y692 D769 H801
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E275 E276 Y669 S755 Y756 Y787 Y791 E211 E212 Y605 S691 Y692 Y723 Y727
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qzw, PDBe:6qzw, PDBj:6qzw
PDBsum6qzw
PubMed
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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