BioLiP

PDB

6qzr AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.

Chain

Resolution

2.3 Å

3D
structure

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Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

peptide

K49 R56 K122 R129 Y130 L174 N175 V178 E182 I219 N226

K54 R61 K121 R128 Y129 L173 N174 V177 E181 I211 N218

Molecular Function

GO:0005515

protein binding

GO:0008426

protein kinase C inhibitor activity

GO:0019901

protein kinase binding

GO:0042802

identical protein binding

GO:0045296

cadherin binding

GO:0050815

phosphoserine residue binding

GO:0051219

phosphoprotein binding

GO:0140311

protein sequestering activity

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0001836	release of cytochrome c from mitochondria
GO:0003334	keratinocyte development
GO:0006469	negative regulation of protein kinase activity
GO:0006611	protein export from nucleus
GO:0007165	signal transduction
GO:0008104	protein localization
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010482	regulation of epidermal cell division
GO:0010839	negative regulation of keratinocyte proliferation
GO:0022407	regulation of cell-cell adhesion
GO:0030216	keratinocyte differentiation
GO:0030307	positive regulation of cell growth
GO:0031424	keratinization
GO:0032880	regulation of protein localization
GO:0043588	skin development
GO:0043616	keratinocyte proliferation
GO:0045606	positive regulation of epidermal cell differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045824	negative regulation of innate immune response
GO:0046827	positive regulation of protein export from nucleus
GO:0051726	regulation of cell cycle
GO:0061436	establishment of skin barrier
GO:0072089	stem cell proliferation
GO:0141156	cAMP/PKA signal transduction
GO:1903077	negative regulation of protein localization to plasma membrane
GO:1903829	positive regulation of protein localization
GO:2000647	negative regulation of stem cell proliferation

Biological Process

GO:0000122

negative regulation of transcription by RNA polymerase II

GO:0001836

release of cytochrome c from mitochondria

GO:0003334

keratinocyte development

GO:0006469

negative regulation of protein kinase activity

GO:0006611

protein export from nucleus

GO:0007165