Structure of PDB 6qxd Chain A

Receptor sequence
>6qxdA (length=287) Species: 1404 (Priestia megaterium) [Search protein sequence]
KYRVRKNVLHLTDTEKRDFVRTVLILKEKGIYDRYIAWHGAAGKFHTPPG
SDRNAAHMSSAFLPWHREYLLRFERDLQSINPEVTLPYWEWETDAQMQDP
SQSQIWSADFMGGNGNPIKDFIVDTGPFAAGRWTTIDEQGNPSGGLKRNF
GATKEAPTLPTRDDVLNALKITQYDTPPWDMTSQNSFRNQLEGFINGPQL
HNRVHRWVGGQMGVVPTAPNDPVFFLHHANVDRIWAVWQIIHRNQNYQPM
KNGPFGQNFRDPMYPWNTTPEDVMNHRKLGYVYDIEL
3D structure
PDB6qxd Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.
ChainA
Resolution2.317 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU A H204 H208 H231 H201 H205 H228
BS02 CU A H42 H60 H69 H39 H57 H66
BS03 JKB A H42 H60 H69 F197 H204 N205 H208 R209 G216 V218 A221 F227 H231 H39 H57 H66 F194 H201 N202 H205 R206 G213 V215 A218 F224 H228 MOAD: ic50=0.96uM
PDBbind-CN: -logKd/Ki=6.02,IC50=0.96uM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6qxd, PDBe:6qxd, PDBj:6qxd
PDBsum6qxd
PubMed31202126
UniProtB2ZB02

[Back to BioLiP]