Structure of PDB 6qx8 Chain A

Receptor sequence
>6qx8A (length=514) Species: 384505 (Influenza A virus (A/nt/60/1968(H3N2))) [Search protein sequence]
ERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMSKE
VNAKIEPFLKTTPRPIRLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGI
PLYDAIKCMRTFFGWKEPYIVKPHEKGINPNYLLSWKQVLAELQDIENEE
KIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDVSDLKQYDSDEPELRS
LSSWIQNEFNKACELTDSTWIELDEIGEDVAPIEYIASMRRNYFTAEVSH
CRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYG
FIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRS
AIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSV
KEKDMTKEFFENKSETWPIGESPKGVEDGSIGKVCRTLLAKSVFNSLYAS
PQLEGFSAESRKLLLVVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLL
NASWFNSFLTHALR
3D structure
PDB6qx8 Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
ChainA
Resolution4.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A K328 W368 A369 L370 G371 E372 M374 A375 P376 E377 K378 Y393 S395 D396 E397 P398 R508 D516 V517 K539 N568 G569 N696 K126 W166 A167 L168 G169 E170 M172 A173 P174 E175 K176 Y191 S193 D194 E195 P196 R306 D314 V315 K337 N366 G367 N494
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qx8, PDBe:6qx8, PDBj:6qx8
PDBsum6qx8
PubMed31485076
UniProtP03434|PA_I68A6 Polymerase acidic protein (Gene Name=PA)

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