Structure of PDB 6qx3 Chain A

Receptor sequence

>6qx3A (length=515) Species: 384505 (Influenza A virus (A/nt/60/1968(H3N2)))

EERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMSK
EVNAKIEPFLKTTPRPIRLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEG
IPLYDAIKCMRTFFGWKEPYIVKPHEKGINPNYLLSWKQVLAELQDIENE
EKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDVSDLKQYDSDEPELR
SLSSWIQNEFNKACELTDSTWIELDEIGEDVAPIEYIASMRRNYFTAEVS
HCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLY
GFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLR
SAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESS
VKEKDMTKEFFENKSETWPIGESPKGVEDGSIGKVCRTLLAKSVFNSLYA
SPQLEGFSAESRKLLLVVQALRDNLEPGTFDLEGLYEAIEECLINDPWVL
LNASWFNSFLTHALR

3D structure

• PDB: 6qx3 Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
• Chain: A
• Resolution: 3.79 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K328 A369 L370 M374 A375 Y393 S395 P398 V517 K539 R566 G569 K574	K127 A168 L169 M173 A174 Y192 S194 P197 V316 K338 R365 G368 K373
BS02	rna	A	G301 R356 T357 E424 Y464 K488 R496	G100 R155 T156 E223 Y263 K287 R295

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6qx3, PDBe:6qx3, PDBj:6qx3
• PDBsum: 6qx3
• PubMed: 31485076
• UniProt: P03434|PA_I68A6 Polymerase acidic protein (Gene Name=PA)