Structure of PDB 6qwi Chain A

Receptor sequence
>6qwiA (length=448) Species: 1406 (Paenibacillus polymyxa) [Search protein sequence]
MTIFQFPQDFMWGTATAAYQIEGAYQEDGRGLSIWDTFAHTPGKVFNGDN
GNVACDSYHRYEEDIRLMKELGIRTYRFSVSWPRIFPNGDGEVNQKGLDY
YHRVVDLLNDNGIEPFCTLYHWDLPQALQDAGGWGNRRTIQAFVQFAETM
FREFHGKIQHWLTFNEPWCIAFLSNMLGVHAPGLTNLQTAIDVGHHLLVA
HGLSVRRFRELGTSGQIGIAPNVSWAVPYSTSEEDKAACARTISLHSDWF
LQPIYQGSYPQFLVDWFAEQGATVPIQDGDMDIIGEPIDMIGINYYSMSV
NRFNPEAGFLQSEEINMGLPVTDIGWPVESRGLYEVLHYLQKYGNIDIYI
TENGACINDEVVNGKVQDDRRISYMQQHLVQVHRAIHDGLHVKGYMAWSL
LDNFEWAEGYSMRFGIIHVDFRTQVRTPKESYYWYRKVVGNNWLETRR
3D structure
PDB6qwi Structural basis of the inhibition of GH1 beta-glucosidases by multivalent pyrrolidine iminosugars.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.21: beta-glucosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JJW A Q20 H121 W122 E166 L173 W326 E352 W398 E405 W406 Q20 H121 W122 E166 L173 W326 E352 W398 E405 W406 PDBbind-CN: -logKd/Ki=4.29,Ki=51uM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0008422 beta-glucosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0016052 carbohydrate catabolic process
GO:0030245 cellulose catabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6qwi, PDBe:6qwi, PDBj:6qwi
PDBsum6qwi
PubMed31226649
UniProtP22073|BGLA_PAEPO Beta-glucosidase A (Gene Name=bglA)

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