Structure of PDB 6qw8 Chain A

Receptor sequence
>6qw8A (length=261) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
ADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAA
AAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAAL
QYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDP
RDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPA
SWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVL
ASAAKIVTDGL
3D structure
PDB6qw8 Molecular Basis of Class A beta-Lactamase Inhibition by Relebactam.
ChainA
Resolution1.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 E166 K234 S237
Catalytic site (residue number reindexed from 1) S43 K46 S103 E139 K207 S210
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MK7 A S70 N104 S130 N132 T216 T235 G236 S237 S43 N77 S103 N105 T189 T208 G209 S210 PDBbind-CN: -logKd/Ki=6.40,IC50=400nM
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6qw8, PDBe:6qw8, PDBj:6qw8
PDBsum6qw8
PubMed31383664
UniProtG3G192

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