Structure of PDB 6qtj Chain A

Receptor sequence
>6qtjA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
SMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDY
ALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDY
AEHDLWHIIKFHRASKLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPAN
ILVMGEGPERGRVKIADMGFVTFWYRAPELLLGARHYTKAIDIWAIGCIF
AELLTSEPIFHCRQSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTL
MKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQA
MQDPYFLEDPLPTSDVFAGCQIPYPKREFL
3D structure
PDB6qtj Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.
ChainA
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D173 T196
Catalytic site (residue number reindexed from 1) D145 K147 N150 D167 T172
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JHK A G28 R29 A50 I79 F97 A100 H106 L158 R356 G29 R30 A51 I80 F98 A101 H107 L152 R327 MOAD: ic50=1.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6qtj, PDBe:6qtj, PDBj:6qtj
PDBsum6qtj
PubMed32024684
UniProtP49336|CDK8_HUMAN Cyclin-dependent kinase 8 (Gene Name=CDK8)

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