Structure of PDB 6qti Chain A

Receptor sequence

>6qtiA (length=1038) Species: 9940 (Ovis aries)

VKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQALVKQGFNVVVESGAGE
ASKFSDDHYRAAGAQIQGAKEVLASDLVVKVRAPMLNPTLGIHEADLLKT
SGTLISFIYPAQNPDLLNKLSKRNTTVLAMDQVPRVTIAQGYDALSSMAN
IAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAK
SMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFI
EAEMKLFAQQCKEVDILISTALIPGKKAPILFNKEMIESMKEGSVVVDLA
AEAGGNFETTKPGELYVHKGITHIGYTDLPSRMATQASTLYSNNITKLLK
AISPDKDNFYFEVKDDFDFGTMGHVIRGTVVMKDGQVIFPAPTPKNIPQG
APVKQKTVAELEAEKAATITPFRKTMTSASVYTAGLTGILGLGIAAPNLA
FSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLVLMG
GHLYPSTTSQGLAALATFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYL
YLLPAGTFVGGYLASLYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLG
NALGMIGVAGGLAATLGGLKPCPELLAQMSGAMALGGTIGLTIAKRIQIS
DLPQLVAAFHSLVGLAAVLTCIAEYIIEYPHFATDAAANLTKIVAYLGTY
IGGVTFSGSLVAYGKLQGILKSAPLLLPGRHLLNAGLLAASVGGIIPFMM
DPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNSYSGWALC
AEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTST
AGGKPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADL
VKMLSEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDF
PDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGV
GYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQ

3D structure

• PDB: 6qti Structure and mechanism of mitochondrial proton-translocating transhydrogenase.
• Chain: A
• Resolution: 2.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R28 R86 F111 Y113 D135 R139 Q144 D147 S150 Y245 E306 D967
• Catalytic site (residue number reindexed from 1): R24 R82 F107 Y109 D131 R135 Q140 D143 S146 Y241 E302 D963
• Enzyme Commision number: 7.1.1.1: proton-translocating NAD(P)(+) transhydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	A786 P789 M833 M837 V922 G924 G964 N966 D967 T968 K999 R1000 D1025 A1026	A782 P785 M829 M833 V918 G920 G960 N962 D963 T964 K995 R996 D1021 A1022
BS02	NAD	A	R139 G191 G192 G193 D214 T215 R216 G244 Y245 A246 E257 L276 I277	R135 G187 G188 G189 D210 T211 R212 G240 Y241 A242 E253 L272 I273

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity

Biological Process

• GO:1902600 proton transmembrane transport

External links

• PDB: RCSB:6qti, PDBe:6qti, PDBj:6qti
• PDBsum: 6qti
• PubMed: 31462775
• UniProt: W5PFI3|NNTM_SHEEP NAD(P) transhydrogenase, mitochondrial (Gene Name=NNT)