Structure of PDB 6qr7 Chain A

Receptor sequence
>6qr7A (length=216) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence]
GSMKIDVVTIFPEYLQPVRQSLPGKAIDAGLVDVAVHDLRRWTHDVHKSV
DDSPYGGGPGMVMKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQW
STEDHLVIACGRYEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVI
IEAVLRLVPGVLGNASLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWR
AEQSRQRTIERRPDLL
3D structure
PDB6qr7 Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
ChainA
Resolution2.03 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P85 E112 R154
Catalytic site (residue number reindexed from 1) P87 E114 R156
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JEK A P83 T84 P85 G109 R110 Y111 E112 S132 G134 Y136 V137 L138 N139 G140 G141 P85 T86 P87 G111 R112 Y113 E114 S134 G136 Y138 V139 L140 N141 G142 G143 MOAD: Kd=70nM
PDBbind-CN: -logKd/Ki=7.15,Kd=70nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qr7, PDBe:6qr7, PDBj:6qr7
PDBsum6qr7
PubMed31282680
UniProtB1MDI3

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