Structure of PDB 6qo6 Chain A

Receptor sequence
>6qo6A (length=206) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence]
SMKIDVVTIFPEYLQPVRQSLPGKVDVAVHDLRRWTHDVHKSVDDSPYGG
GPGMVMKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQWSTEDHLV
IACGRYEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVIIEAVLRL
VPGVSLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWRAEQSRQRTIER
RPDLLG
3D structure
PDB6qo6 Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
ChainA
Resolution1.745 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P85 E112 R154
Catalytic site (residue number reindexed from 1) P80 E107 R149
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5OB A P83 T84 P85 Y111 S132 I133 Y136 L138 G140 G141 P78 T79 P80 Y106 S127 I128 Y131 L133 G135 G136
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qo6, PDBe:6qo6, PDBj:6qo6
PDBsum6qo6
PubMed32602532
UniProtB1MDI3

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