Structure of PDB 6qns Chain A

Receptor sequence
>6qnsA (length=430) Species: 1491 (Clostridium botulinum) [Search protein sequence]
NNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLTSSANSKIRV
TQNQNIIFNSVFLDFSVSFWIRIPKYKNDGIQNYIHNEYTIINCMKNNSG
WKISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRWFFVTITNNL
NNAKIYINGKLESNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYFSI
FNTELSQSNIEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSYIK
LKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRRKSNSQSINDDIV
RKEDYIYLDFFNLNQEWRVYTYKYFKKEEEKLFLAPISDSDEFYNTIQIK
EYDEQPTYSCQLLFKKDEESTDEIGLIGIHRFYESGWWFEEYKDYFCISK
WYLKEVKRKPYNLKLGCNWQFIPKDEGWTE
3D structure
PDB6qns Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K1113 S1116 P1117 V1118 E1191 K1192 F1194 P1197 S1199 E1203 K252 S255 P256 V257 E330 K331 F333 P336 S338 E342
BS02 GAL A E1190 I1240 H1241 S1260 W1262 E329 I379 H380 S399 W401
BS03 SIA A G1104 N1105 Y1263 G1277 G243 N244 Y402 G416
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:6qns, PDBe:6qns, PDBj:6qns
PDBsum6qns
PubMed32182233
UniProtP10844|BXB_CLOBO Botulinum neurotoxin type B (Gene Name=botB)

[Back to BioLiP]