Structure of PDB 6qmt Chain A

Receptor sequence
>6qmtA (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGK
VQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKAT
LGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLD
RATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG
SRVCGNRKKPGIYTRVASYAAWIDSVLASA
3D structure
PDB6qmt Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H41 D89 K180 G181 D182 S183
Enzyme Commision number 3.4.21.46: complement factor D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J7B A L41 C42 H57 D61 D189 S190 C191 K192 G193 S195 S215 R218 C220 L25 C26 H41 D45 D177 S178 C179 K180 G181 S183 S199 R202 C204 MOAD: ic50=0.12uM
PDBbind-CN: -logKd/Ki=6.92,IC50=0.120uM
BindingDB: IC50=120nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6qmt, PDBe:6qmt, PDBj:6qmt
PDBsum6qmt
PubMed30995036
UniProtP00746|CFAD_HUMAN Complement factor D (Gene Name=CFD)

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