Structure of PDB 6qkg Chain A

Receptor sequence

>6qkgA (length=661) Species: 700510 (bacterium enrichment culture clone N47) [Search protein sequence]

MYENLCKPIKIGNHLVKNRMKYAATVDNFCDTKNGNVIDREIEYLRERAK
GGFGIVVSQGGYTHILGKGYVGQMGLVEESHLPGLKKLADAINAEGAMSI
GQIMHTGRYGHAHEYGIHEAIAGGKTVGPEPVGPTAMSSPIKRYSPCREM
TPEEIEEQIQAHIVAARMFKQTGWKGVEVCAIVGYLIADFLSRWTNKRTD
KWGGSLENRARFLIEILKGIRKEVGDDYPLVMRLNSTDLIEGGNTDEEYI
EIAKMCEAAVRIDLFSITVGWHESPGAAITAEKRPGDWLHLADNWKKAGI
KAPICMAYRMNQPDVAEKAVAEGRIDIWEMCRPGIADPYLPKKVCEGRPE
DIVTCTACNQGCFYYVFIDAIMGCMVNPRVGNEWDPAYAINPAAKKKKVL
VVGAGPSGMECARLAAVRGHDVTIMEKSDSIGGEVKLGVKSPLLYDWAET
IRYYKAQIDKLGIKLKLNTEATADSIKAEAPDVLVIATGGKPSRPKIEGI
DNKIVTNVFDILEGKVKLGDKVVFIGGNEISIQTAEYVAEQGKEVTVLEK
GKHICFDVNIFNILQHRRLMAKLNMKSMTNVTINEINDDGVEISTAGGKD
VTIEADNVVVAEGMDADDALAKAVGTKIAPEVYSIGDCAGVRKLYEAIHD
GYKMGVKIRGS

3D structure

PDB

6qkg Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors.

Chain

Resolution

2.2 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	V38 C192 V195 Y197 R245 E253 H284 Q372
Catalytic site (residue number reindexed from 1)	V26 C180 V183 Y185 R233 E241 H272 Q360
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	SF4	A	R344 I347 C367 A369 C370 N371 G373 C374 C386 M387	R332 I335 C355 A357 C358 N359 G361 C362 C374 M375
BS02	FAD	A	V414 G415 G417 P418 S419 E438 K439 G445 E446 G450 W459 A483 T500 G501 E541 I542 Q545 G648 D649 K655 L656	V402 G403 G405 P406 S407 E426 K427 G433 E434 G438 W447 A471 T488 G489 E529 I530 Q533 G636 D637 K643 L644
BS03	FMN	A	A36 T37 V38 Q114 M116 R245 Y320 M342 C343 R344 F375	A24 T25 V26 Q102 M104 R233 Y308 M330 C331 R332 F363

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0009056	catabolic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6qkg, PDBe:6qkg, PDBj:6qkg
PDBsum	6qkg
PubMed	31061390
UniProt	E1YD54

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