Structure of PDB 6qig Chain A

Receptor sequence
>6qigA (length=581) Species: 9606 (Homo sapiens) [Search protein sequence]
ILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHL
VKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYI
TRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHQIGH
SFGLEHDGAPGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGR
ARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREH
LDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELT
PIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADL
QAEMCNTQACEKTQLEFMSQQCARTHWGAAVPHSQGDALCRHMCRARGDS
FLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGD
NSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGG
RYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQE
DADIQVYRRYGEEYGNLTRPDITFTYFQPKP
3D structure
PDB6qig Crystal structure and substrate-induced activation of ADAMTS13.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.87: ADAMTS13 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H224 H228 H234 H146 H150 H156
BS02 CA A D182 L183 R190 V192 E212 D104 L105 R112 V114 E134
BS03 CA A E83 D166 D173 C281 D284 E5 D88 D95 C203 D206
BS04 CA A E83 D166 E5 D88
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0030198 extracellular matrix organization

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Molecular Function
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Biological Process
External links
PDB RCSB:6qig, PDBe:6qig, PDBj:6qig
PDBsum6qig
PubMed31439947
UniProtQ76LX8|ATS13_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 13 (Gene Name=ADAMTS13)

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