Structure of PDB 6qie Chain A

Receptor sequence

>6qieA (length=703) Species: 759272 (Thermochaetoides thermophila DSM 1495)

GTTAKQAEAVEDSDINPWTGQRHSERYFKILKARRKLPVNKQRQEFLDLY
HNNQILVFVGETGSGKTTQIPQYVLYDELPHQTGKLIACTQPRRVAAMSV
AQRVADELDVKLGEEVGYSIRFENKTSSKTLLKYMTDGQLLREAMHDRDM
SRYSCIILDEAHERTLATDILMALLKQLSERRKDLKIIVMSATLDAQKFQ
SYFFNAPLLAVPGRTHPVEIFYTPEAERDYVEAAIRTVLQIHACEPEGDI
LLFLTGEEEIEDACRRISLEVDEMIRESDAGPMSVYPLYGTLPPHQQQRI
FEKAPQPFRPGGRPGRKCIVATNIAETGLTIDGIVYVVDPGFSKQKIYNP
RTRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFKKELIEQTY
PEILRSNLSNTVLELKKLGVEDLVHFDLMDPPAPETMMRALEELNYLACL
DDDGELTPLGNLASEFPLDPALAVMLISSPEFYCSNEILSITSLLSVPQI
WVRPANARKRADEMKAQFAHPDGDHLTLLNAYHAYKGAEARGEDMKKWCH
EHFLSYRHLSSADNVRAQLKKIMETHGIELVSTPFHDKNYYTNIRRALLA
GFFMQVAMRESSNSKVYKTVKDEQLVLIHPSTTVTTPYEWVVYNEFVLTT
KQYVRTVTNIRPEWLLEIAPVYYDLSTFQKGEIKNALTRVAEKIRRQQAM
KAS

3D structure

• PDB: 6qie Structural basis for RNA translocation by DEAH-box ATPases.
• Chain: A
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	T121 G122 G124 K125 T126 T127 R162 T389 R435 T436	T62 G63 G65 K66 T67 T68 R103 T330 R376 T377
BS02	MG	A	T126 E219	T67 E160
BS03	BEF	A	T121 K125 E219 R432 R435	T62 K66 E160 R373 R376

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005681 spliceosomal complex
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6qie, PDBe:6qie, PDBj:6qie
• PDBsum: 6qie
• PubMed: 30828714
• UniProt: G0RY84