Structure of PDB 6qhw Chain A

Receptor sequence
>6qhwA (length=297) Species: 1076 (Rhodopseudomonas palustris) [Search protein sequence]
DLADLFPGFGSEWINTSSGRIFARVGGDGPPLLLLHGFPQTHVMWHRVAP
KLAERFKVIVADLPGYGWSDMPESDEQHTPYTKRAMAKQLIEAMEQLGHV
HFALAGHDRGARVSYRLALDSPGRLSKLAVLDILPTYEYWQRMNRAYALK
IYHWSFLAQPAPLPENLLGGDPDFYVKAKLASWTRAGDLSAFDPRAVEHY
RIAFADPMRRHVMCEDYRAGAYADFEHDKIDVEAGNKIPVPMLALWGASG
IAQSAATPLDVWRKWASDVQGAPIESGHFLPEEAPDQTAEALVRFFS
3D structure
PDB6qhw Time-resolved crystallography reveals allosteric communication aligned with molecular breathing.
ChainA
Resolution1.718 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F40 D110 R111 H155 Y219 G252 H280
Catalytic site (residue number reindexed from 1) F38 D108 R109 H153 Y217 G250 H278
Enzyme Commision number 3.8.1.3: haloacetate dehalogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOA A D110 R114 W156 D108 R112 W154
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0018785 haloacetate dehalogenase activity

View graph for
Molecular Function
External links
PDB RCSB:6qhw, PDBe:6qhw, PDBj:6qhw
PDBsum6qhw
PubMed31515393
UniProtQ6NAM1|DEHA_RHOPA Fluoroacetate dehalogenase (Gene Name=RPA1163)

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