Structure of PDB 6qhr Chain A

Receptor sequence
>6qhrA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
KQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQ
MRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMG
TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNIL
LDERGQIKLCDFGISGRLAGCAAYMAPERIDPPYDIRADVWSLGISLVEL
ATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDH
RKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKT
3D structure
PDB6qhr Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).
ChainA
Resolution2.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D259 K261 N264 D277 C296
Catalytic site (residue number reindexed from 1) D143 K145 N148 D161 C171
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J3N A S144 K165 M212 E213 M215 C218 K221 S28 K49 M96 E97 M99 C102 K105 PDBbind-CN: -logKd/Ki=7.72,IC50=19nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6qhr, PDBe:6qhr, PDBj:6qhr
PDBsum6qhr
PubMed31083997
UniProtO14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (Gene Name=MAP2K7)

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