Structure of PDB 6qgv Chain A

Receptor sequence
>6qgvA (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHGDKITWI
EGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTG
YVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPK
FDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGE
3D structure
PDB6qgv Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H313 D315 H374 H104 D106 H165
BS02 J2H A W258 T296 M299 Y310 H313 D315 D320 R322 H374 V376 W389 F391 W49 T87 M90 Y101 H104 D106 D111 R113 H165 V167 W180 F182 MOAD: ic50=0.127uM
BindingDB: IC50=2.1nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6qgv, PDBe:6qgv, PDBj:6qgv
PDBsum6qgv
PubMed31057728
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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