Structure of PDB 6qfq Chain A

Receptor sequence
>6qfqA (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB6qfq Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J3E A A227 F228 M250 V253 R263 L267 F270 G271 I294 A56 F57 M79 V82 R92 L96 F99 G100 I123 PDBbind-CN: -logKd/Ki=7.10,Kd=0.08uM
BindingDB: IC50=100nM
BS02 J3E A H224 N260 G262 F318 F319 H53 N89 G91 F147 F148 PDBbind-CN: -logKd/Ki=7.10,Kd=0.08uM
BindingDB: IC50=100nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
Biological Process
GO:0042981 regulation of apoptotic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6qfq, PDBe:6qfq, PDBj:6qfq
PDBsum6qfq
PubMed31459977
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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