Structure of PDB 6qfe Chain A

Receptor sequence
>6qfeA (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
IINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRV
RLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPT
KDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKR
CEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPC
ARPNRPGVYTNLCKFTKWIQETIQANS
3D structure
PDB6qfe Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
ChainA
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D87 Q176 G177 D178 S179 G180
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J08 A H57 H96 D189 S190 C191 Q192 S195 V213 S214 W215 G216 D217 Y218 C220 H42 H81 D173 S174 C175 Q176 S179 V193 S194 W195 G196 D197 Y198 C200 MOAD: ic50=0.08uM
PDBbind-CN: -logKd/Ki=7.10,IC50=0.08uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6qfe, PDBe:6qfe, PDBj:6qfe
PDBsum6qfe
PubMed31045568
UniProtQ9Y337|KLK5_HUMAN Kallikrein-5 (Gene Name=KLK5)

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