Structure of PDB 6qf3 Chain A

Receptor sequence

>6qf3A (length=316) Species: 1427 (Bacillus thermoproteolyticus) [Search protein sequence]

ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTL
PGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAI
RSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTD
YTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGD
SLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTH
YGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTS
QEVASVKQAFDAVGVK

3D structure

PDB

6qf3 On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies.

Chain

Resolution

1.521 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H142 E143 H146 Y157 E166 D226 H231
Catalytic site (residue number reindexed from 1)	H142 E143 H146 Y157 E166 D226 H231
Enzyme Commision number	3.4.24.27: thermolysin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	H142 H146 E166	H142 H146 E166
BS02	CA	A	D138 E177 D185 E187 E190	D138 E177 D185 E187 E190
BS03	CA	A	E177 N183 D185 E190	E177 N183 D185 E190
BS04	CA	A	D57 D59 Q61	D57 D59 Q61
BS05	CA	A	Y193 T194 I197 D200	Y193 T194 I197 D200
BS06	ASP	A	H142 E143 H146 Y157 E166 H231	H142 E143 H146 Y157 E166 H231
BS07	ASP	A	H142 E143 R203 H231	H142 E143 R203 H231

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6qf3, PDBe:6qf3, PDBj:6qf3
PDBsum	6qf3
PubMed	31316815
UniProt	P00800\|THER_BACTH Thermolysin (Gene Name=npr)

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