Structure of PDB 6qee Chain A

Receptor sequence

>6qeeA (length=1182) Species: 9606 (Homo sapiens)

PAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGEMTDIFAN
AGNLEDLMSNITNRSDINDTGFFMNLEEDMTTYAYYYTGIGAGVLIVAYI
QVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSK
INEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGI
WAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNL
EEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTTLVLSGEYSIGQV
LTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKS
GHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGC
GKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFA
TTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQL
SGGQKQRIAIARALVRNPKILLLDQATSALDTESEAVVQAALDKAREGRT
TIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTP
ASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKIIGVFTRIDD
PETKRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFK
SMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLG
TGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSG
KIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSF
TQAMMYFSYAACFRFGAYLVAHKLMSFEDVLLVFSAIVFGAMAVGQVSSF
APDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNY
PTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSV
FLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEE
IVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQP
HILLLDQATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV
VIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAG

3D structure

• PDB: 6qee Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.
• Chain: A
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZQU	A	F302 L338 F342 A986 Q989 V990	F272 L308 F312 A893 Q896 V897
BS02	ZQU	A	L64 W231 Q346 M875 M948 F982 M985	L34 W201 Q316 M782 M855 F889 M892
BS03	CLR	A	A307 W314 L759	A277 W284 L666
BS04	CLR	A	T118 M947 F950	T88 M854 F857
BS05	CLR	A	L859 R957	L766 R864
BS06	CLR	A	Y116 G119	Y86 G89

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Fri Nov 15 16:27:09 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6qee', asym_id = 'A', title = 'Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6qee', asym_id='A', title='Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005524,0016020,0016887,0055085,0140359', uniprot = '', pdbid = '6qee', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005524,0016020,0016887,0055085,0140359', uniprot='', pdbid='6qee', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>