Structure of PDB 6qdx Chain A

Receptor sequence
>6qdxA (length=273) Species: 562 (Escherichia coli) [Search protein sequence]
SYRHSFHAGNHADVLKHTVQSLIIESLKEKDKPFLYLDTHAGAGRYQLGR
TGKYLEGIARIWQQDDLPAELEAYINVVKHFNRSGQLRYYPGSPLIARQL
LREQDSLQLTELHPSDYPLLRSEFQKDSRARVEKADGFQQLKAKLPPVSR
RGLILIDPPYEMKTDYQAVVSGIAEGYKRFATGTYALWYPVVLRQQIKRM
IHDLEATGIRKILQIELAVLPDSDRRGMTASGMIVINPPWKLEQQMNNVL
PWLHSKLVPAGTGHATVSWIVPE
3D structure
PDB6qdx Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.266: 23S rRNA (adenine(2030)-N(6))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HY8 A H9 D15 K18 H42 A43 G44 S100 D164 P166 E168 M235 H7 D13 K16 H40 A41 G42 S93 D157 P159 E161 M228 MOAD: Kd=30uM
PDBbind-CN: -logKd/Ki=4.52,Kd=30uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008649 rRNA methyltransferase activity
GO:0008988 rRNA (adenine-N6-)-methyltransferase activity
GO:0036307 23S rRNA (adenine(2030)-N(6))-methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0015976 carbon utilization
GO:0032259 methylation
GO:0070475 rRNA base methylation
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6qdx, PDBe:6qdx, PDBj:6qdx
PDBsum6qdx
PubMed30879411
UniProtP37634|RLMJ_ECOLI Ribosomal RNA large subunit methyltransferase J (Gene Name=rlmJ)

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