Structure of PDB 6qcx Chain A

Receptor sequence
>6qcxA (length=718) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence]
SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYTAQNLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKY
LADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSL
SNESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQ
TISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKK
LTWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLA
KECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNEL
QKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTE
MNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMM
KYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSH
LRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLY
CRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKG
DRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSA
ESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEW
LGFEKEGSKVLESVDEIM
3D structure
PDB6qcx Structural snapshots of actively transcribing influenza polymerase.
ChainA
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A M473 H506 R508 K564 M467 H500 R502 K558
BS02 rna A K330 T366 G367 G369 T371 Y372 P391 K392 I393 P394 H506 R508 D512 V513 T515 V559 N560 G561 Q566 N692 K324 T360 G361 G363 T365 Y366 P385 K386 I387 P388 H500 R502 D506 V507 T509 V553 N554 G555 Q560 N686
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qcx, PDBe:6qcx, PDBj:6qcx
PDBsum6qcx
PubMed31160782
UniProtQ5V8Z9

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