Structure of PDB 6qcs Chain A

Receptor sequence

>6qcsA (length=715) Species: 11520 (Influenza B virus)

MDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVISD
MNFLDEEGKAYTANLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLA
DLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSN
ESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQTI
SRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLT
WEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKE
CLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQK
TNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMN
LLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKY
VLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLR
GDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCR
VNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDR
VNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAES
RRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLG
FEKEGSKVLESVDEI

3D structure

• PDB: 6qcs Structural snapshots of actively transcribing influenza polymerase.
• Chain: A
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K330 T366 G369 L370 T371 P391 P394 H506 V513 T515 R558 N560 G561	K322 T358 G361 L362 T363 P383 P386 H498 V505 T507 R550 N552 G553
BS02	rna	A	M473 H506 R508	M465 H498 R500
BS03	MG	A	E81 D109	E73 D101

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6qcs, PDBe:6qcs, PDBj:6qcs
• PDBsum: 6qcs
• PubMed: 31160782
• UniProt: Q5V8Z9