Structure of PDB 6q8z Chain A

Receptor sequence
>6q8zA (length=392) Species: 9606 (Homo sapiens) [Search protein sequence]
HAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQG
LVLPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLE
PGTPRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATY
TFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALL
IDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVARAL
GKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDY
RAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGG
CTVTLLEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
3D structure
PDB6q8z Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL A E43 H44 D46 Y47 G183 M185 D186 Y236 G345 G346 E43 H44 D46 Y47 G183 M185 D186 Y236 G345 G346
BS02 HFK A R105 Y109 V129 L135 G136 S141 S142 R105 Y109 V129 L135 G136 S141 S142
BS03 HR5 A V9 L13 A31 V32 S33 K388 L390 V9 L13 A31 V32 S33 K388 L390
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0019402 galactitol metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
GO:0061623 glycolytic process from galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q8z, PDBe:6q8z, PDBj:6q8z
PDBsum6q8z
PubMed
UniProtP51570|GALK1_HUMAN Galactokinase (Gene Name=GALK1)

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