Structure of PDB 6pz3 Chain A

Receptor sequence

>6pz3A (length=429) Species: 9606 (Homo sapiens)

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAA
IERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIR
KIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCR
GIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLT
KDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVI
KNMNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 6pz3 Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
• Chain: A
• Resolution: 2.395 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	S113 E116 K224 S257 G259 G260 K261 L262 L381 R382 C384	S113 E116 K221 S254 G256 G257 K258 L259 L378 R379 C381
BS02	dna	A	Q38 Y39 W42 G46 I47 I48 S62 W64 K86 R93 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351	Q38 Y39 W42 G46 I47 I48 S62 W64 K86 R93 K308 R310 P313 K314 T315 G317 S319 K320 N321 P323 G324 R348
BS03	XG4	A	D13 M14 D15 C16 F17 F18 I48 Y52 R55 R61 D115 K231	D13 M14 D15 C16 F17 F18 I48 Y52 R55 R61 D115 K228
BS04	MG	A	D13 M14 D115	D13 M14 D115
BS05	MG	A	D13 D115 E116	D13 D115 E116

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6pz3, PDBe:6pz3, PDBj:6pz3
• PDBsum: 6pz3
• PubMed: 31704958
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)