Structure of PDB 6pz0 Chain A

Receptor sequence
>6pz0A (length=185) Species: 309803 (Thermotoga neapolitana DSM 4359) [Search protein sequence]
KMLYDLAKKRKTVRRFKKEKPPLEDLIYSLKVANEAPSGMNAQPWRFLIV
EDEKLKGQIRRVCERSEKTFYENVRGRLKEWLDEKRFTWRKPFLKEAPYL
LLVFSEKSAPYSRESVWLAVGYLLLALEEKGLGSVPYTPPDFREVEKLVN
TPSELRLEVILPVGYPDDPKPKYPRNEVIVRYNTF
3D structure
PDB6pz0 The minimal structure for iodotyrosine deiodinase function is defined by an outlier protein from the thermophilic bacterium Thermotoga neapolitana.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.21.1.1: iodotyrosine deiodinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A K12 T13 R15 W82 V136 P137 Y138 T139 K173 Y174 R176 K11 T12 R14 W81 V135 P136 Y137 T138 K172 Y173 R175
BS02 TYR A E68 Y72 L83 K92 E67 Y71 L82 K91
BS03 FMN A P38 S39 G40 N42 S116 P37 S38 G39 N41 S115
Gene Ontology
Molecular Function
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0072545 L-tyrosine binding
GO:0140616 iodotyrosine deiodinase activity
Biological Process
GO:0006570 tyrosine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6pz0, PDBe:6pz0, PDBj:6pz0
PDBsum6pz0
PubMed34748729
UniProtB9K712|IYD_THENN Iodotyrosine deiodinase (Gene Name=IYD)

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