Structure of PDB 6pyw Chain A

Receptor sequence

>6pywA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAP
WIEQEGPEYADRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYG
CDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAA
RVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRWEP

3D structure

PDB

6pyw Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation.

Chain

Resolution

1.38 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y7 T24 E45 R62 E63 I66 C67 E76 D77 L81 Y84 L95 Y99 D116 Y123 T143 K146 W147 V152 Q155 L156 Y159 W167 Y171	Y7 T24 E45 R62 E63 I66 C67 E76 D77 L81 Y84 L95 Y99 D116 Y123 T143 K146 W147 V152 Q155 L156 Y159 W167 Y171

External links

PDB	RCSB:6pyw, PDBe:6pyw, PDBj:6pyw
PDBsum	6pyw
PubMed	31740583
UniProt	P01889\|HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain (Gene Name=HLA-B)

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