Structure of PDB 6pyf Chain A

Receptor sequence

>6pyfA (length=175) Species: 9606 (Homo sapiens) [Search protein sequence]

PAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPK
DDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVL
LEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDG
CLRRDSWLDKQAKISASAPTSLRSC

3D structure

PDB

6pyf Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.

Chain

Resolution

1.73 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D50 E52 A160	D37 E39 A147
BS02	EST	A	S42 G58 D65 F67 N82 K134 I141	S29 G45 D52 F54 N69 K121 I128	BindingDB: IC50=50nM,Kd=1.5nM

External links

PDB	RCSB:6pyf, PDBe:6pyf, PDBj:6pyf
PDBsum	6pyf
PubMed	31852737
UniProt	P04278\|SHBG_HUMAN Sex hormone-binding globulin (Gene Name=SHBG)

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