Structure of PDB 6pxu Chain A

Receptor sequence
>6pxuA (length=526) Species: 9606 (Homo sapiens) [Search protein sequence]
GPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRL
HQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWS
TLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLI
RANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEES
AVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQS
PVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCG
GVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNP
RARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQ
NKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNT
HQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQA
ARSFVPLLRDCTNSDHQKWFFKERML
3D structure
PDB6pxu The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function.
ChainA
Resolution2.007 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V259 F285 W287 W335 F365 R373 V209 F235 W237 W285 F315 R323
BS02 UDP A A143 Y145 D176 R205 G207 L208 D228 C229 H230 V334 W335 H363 Y371 R373 A93 Y95 D126 R155 G157 L158 D178 C179 H180 V284 W285 H313 Y321 R323
BS03 MN A D228 H230 H363 D178 H180 H313
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pxu, PDBe:6pxu, PDBj:6pxu
PDBsum6pxu
PubMed31548401
UniProtQ8IXK2|GLT12_HUMAN Polypeptide N-acetylgalactosaminyltransferase 12 (Gene Name=GALNT12)

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