Structure of PDB 6pwy Chain A

Receptor sequence
>6pwyA (length=504) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
MEPKHIINDNVYGTVKVPRPIDKLIDTVEFQRLRHLKQTGLVYLVYPNCE
HSRFVHSLGTFSLAYALVDKLRHSQPSLNITESDLICTSVAALLRNVGHG
PFSHLFDGEFAKRNGSRFKHEDMSILIIKKIMNKPEIKSEFACILGETDE
EYAKSVTLITELISGKPFDFQDMDGFKDLPADVREETVKNEWAIIGCGPE
KSFLFDVVSNSYNGHDVDKMDYLLRDSKASGVGITFSESTLERLFNHVRV
VIDPNSGLKRIAYSIKCIGDLKAIGDSRQELHSKVYQHKAVRFMETLMVD
ALINAGDFLKYKGSNGELYSLKNVTEDVDAFLKTTDYVEQEILNSQITDP
KMIEAQTALLKIQRREIGCKLGYFEMNPENATAAEVVKKVGQKMKEILEQ
MDDTEEMDGKLKDIQFTVMHSVLGRGLDDKTHPIERQIFYDGKPSQVVGF
YPSEDYVINNCPRMATKWEIFVMGDRSLRKEPLLADRVKRALQLAGESEK
FLTP
3D structure
PDB6pwy ZK177.8 of Caenorhabditis elegans: Aicardi-Goutieres Syndrome SAMHD1 Ortholog
ChainA
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTP A Q77 T78 R134 H143 Y261 D265 R317 H321 Y325 Q38 T39 R95 H104 Y222 D226 R278 H282 Y286
BS02 GTP A L83 V84 P86 R404 K409 R534 L44 V45 P47 R365 K370 R479
BS03 DTP A V84 Y85 H327 K409 V45 Y46 H288 K370
BS04 DTP A R282 K305 K493 R243 K266 K443
BS05 GTP A H44 I46 D65 R73 H5 I7 D26 R34
BS06 DTP A I45 N47 I6 N8
External links
PDB RCSB:6pwy, PDBe:6pwy, PDBj:6pwy
PDBsum6pwy
PubMed
UniProtQ09374|SAMH1_CAEEL Deoxynucleoside triphosphate triphosphohydrolase sahd-1 (Gene Name=sahd-1)

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