Structure of PDB 6prt Chain A

Receptor sequence
>6prtA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
SNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6prt Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OWA A F83 L92 N140 F41 L50 N98 MOAD: ic50=2120uM
PDBbind-CN: -logKd/Ki=2.67,IC50=2120uM
BindingDB: IC50=2120000nM
External links
PDB RCSB:6prt, PDBe:6prt, PDBj:6prt
PDBsum6prt
PubMed31727451
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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