Structure of PDB 6prf Chain A

Receptor sequence
>6prfA (length=99) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]
PQITLWKRPFVTVKVGGQLKEALLDTGADNTIFEDINLPGRWKPKMVGGI
GGFLKVREYDQVPIEIAGHKVIGTVLVGPTPVNVIGRDTMTQIGATLNF
3D structure
PDB6prf Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20.
ChainA
Resolution1.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7OA A D25 G27 D29 N30 I32 V47 G48 G49 I50 D25 G27 D29 N30 I32 V47 G48 G49 I50
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6prf, PDBe:6prf, PDBj:6prf
PDBsum6prf
PubMed31474336
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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