Structure of PDB 6pr4 Chain A

Receptor sequence
>6pr4A (length=451) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium) [Search protein sequence]
MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLEAGARLTVNALTFIPQFT
VWANEGMLTLVEGPFDETLLDSCWLAIAATDDDTVNQRVSDAAESRRIFC
NVVDAPKAASFIMPSIIDRSPLMVAVSAGGTSPVLARLLREKLESLLPQH
LGQVARYAGQLRARVKKQFATMGERRRFWEKFFVNDRLAQSLANADEKAV
NATTERLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRL
VSDDIMNLVRRNADRVFVGKVPQEEINQILLREAQKGKRVVRLKGGDPFI
FGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLV
TGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMQADMPVA
LVENGTSVKQRVVHGVLTQLGELAQQVESPALIIVGRVVALRDKLNWFSN
H
3D structure
PDB6pr4 Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.76: precorrin-2 dehydrogenase.
2.1.1.107: uroporphyrinogen-III C-methyltransferase.
4.99.1.4: sirohydrochlorin ferrochelatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A L250 G301 G302 D303 I306 F307 T331 A332 C336 Y381 M382 N410 G411 P436 A437 L438 L250 G295 G296 D297 I300 F301 T325 A326 C330 Y375 M376 N404 G405 P430 A431 L432
Gene Ontology
Molecular Function
GO:0004325 ferrochelatase activity
GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0016491 oxidoreductase activity
GO:0016829 lyase activity
GO:0043115 precorrin-2 dehydrogenase activity
GO:0051266 sirohydrochlorin ferrochelatase activity
GO:0051287 NAD binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0009236 cobalamin biosynthetic process
GO:0019354 siroheme biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6pr4, PDBe:6pr4, PDBj:6pr4
PDBsum6pr4
PubMed32054833
UniProtP25924|CYSG_SALTY Siroheme synthase (Gene Name=cysG)

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