Structure of PDB 6pq3 Chain A

Receptor sequence
>6pq3A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYILDTAGQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDQAFYTLVREIRKHK
3D structure
PDB6pq3 RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 V29 D30 N126 K127 D129 L130 S155 A156 K157 G13 V14 G15 K16 S17 A18 F28 V29 D30 N117 K118 D120 L121 S146 A147 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pq3, PDBe:6pq3, PDBj:6pq3
PDBsum6pq3
PubMed32393580
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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