Structure of PDB 6pp9 Chain A

Receptor sequence
>6pp9A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
SDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQ
AFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIET
KFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFG
LATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVL
YELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAEC
LKKKRDERPLFPQILASIELLARSLP
3D structure
PDB6pp9 Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
ChainA
Resolution2.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D130 K132 N134 N135 D148 S170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A I463 G466 S467 V471 A481 K483 W531 C532 D576 K578 N580 N581 F583 D594 I17 G20 S21 V25 A35 K37 W85 C86 D130 K132 N134 N135 F137 D148
BS02 MG A N581 D594 N135 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6pp9, PDBe:6pp9, PDBj:6pp9
PDBsum6pp9
PubMed31581174
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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