Structure of PDB 6pnx Chain A

Receptor sequence
>6pnxA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
ELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTV
AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV
EYAAKGNLREFLRARRPPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHR
DLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEAL
FDEVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP
ANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTST
3D structure
PDB6pnx Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation.
ChainA
Resolution2.199 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D617 R621 N622 D635
Catalytic site (residue number reindexed from 1) D151 R155 N156 D169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A L478 E480 F483 A506 Y557 A558 L624 L23 E25 F28 A51 Y102 A103 L158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6pnx, PDBe:6pnx, PDBj:6pnx
PDBsum6pnx
PubMed31959966
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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