Structure of PDB 6pnl Chain A

Receptor sequence

>6pnlA (length=336) Species: 145262 (Methanothermobacter thermautotrophicus) [Search protein sequence]

HPFTMIMDEFRAYDGKCVLVTGGAGCVGSNLTGNLAKAGANVIILDNLSS
SYEWNIPEYENIEFVKGDILDDEVLKRVFKERPDYVFHLAAHFANQNSVD
NPEKDLLVNGLGILKVLEYAQLVGVERFVYSSSGCGVYGLDSKIPFEEHD
ISISLHTPYQVTKLLGELYTNYFHNLYEMPIVNARFFNVFGPGEVPGKYR
NVIPNFFYWAMNQQPLPITGDGSETRDWTFVEDIVRGLMAMGVRREAIGE
AINLGSGTEHQVIEMAGIINELTENPAGVVYRPRRDWDAKTRLLSSIDKA
RRLLDYEPQVSFREGLERTHRWFTENWELIRKSAEF

3D structure

PDB

6pnl Structure of a UDP-GALE 4-epimerase (Mth375) from the thermophilic pseudomurein-containing methanogen Methanothermobacter thermautotrophicus

Chain

Resolution

2.01 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	S129 C131 G132 Y155 K159
Catalytic site (residue number reindexed from 1)	S133 C135 G136 Y159 K163
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G18 G21 C22 D42 N43 L44 S45 S46 S47 D64 I65 L85 A87 F89 V104 S127 S129 Y155 K159 F182 N184 V185 R196	G22 G25 C26 D46 N47 L48 S49 S50 S51 D68 I69 L89 A91 F93 V108 S131 S133 Y159 K163 F186 N188 V189 R200
BS02	UDP	A	N184 N197 V198 F202 P213 I214 T215 R222 V258 R281	N188 N201 V202 F206 P217 I218 T219 R226 V262 R285

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding

View graph for
Molecular Function

External links

PDB	RCSB:6pnl, PDBe:6pnl, PDBj:6pnl
PDBsum	6pnl
PubMed
UniProt	O26475

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