Structure of PDB 6pme Chain A

Receptor sequence
>6pmeA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
ACVHHIKRRDIVLKWELGEGAFGKVFLAECHNKMLVAVKALKEASESARQ
DFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHG
PDGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIG
DFGMSRDIYSTDYYRVTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQ
RHSIKDVHARLQALAQAP
3D structure
PDB6pme Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA).
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D650 R654 N655 D668
Catalytic site (residue number reindexed from 1) D133 R137 N138 D151
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H504 C579 E581 H5 C74 E76
BS02 OOY A L516 A542 F589 Y591 M592 G595 D596 L657 G667 F669 L17 A37 F84 Y86 M87 G90 D91 L140 G150 F152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6pme, PDBe:6pme, PDBj:6pme
PDBsum6pme
PubMed33479642
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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