Structure of PDB 6plo Chain A

Receptor sequence
>6ploA (length=346) Species: 7955 (Danio rerio) [Search protein sequence]
PMPPSEFLDKLMGKVSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTM
DYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGA
NFHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQTCIMQL
ESYGFTMNDLIFEWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGK
FTCIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLG
ITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNF
IARQHVEEMRKLFISRAKRIDTVSRVAFPLVFLIFNIFYWITYKII
3D structure
PDB6plo Mechanism of gating and partial agonist action in the glycine receptor.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU A F79 R81 S145 F57 R59 S123
BS02 ABU A Y175 Y218 T220 F223 Y153 Y196 T198 F201
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0016594 glycine binding
GO:0016934 extracellularly glycine-gated chloride channel activity
GO:0022824 transmitter-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:6plo, PDBe:6plo, PDBj:6plo
PDBsum6plo
PubMed33567265
UniProtO93430|GLRA1_DANRE Glycine receptor subunit alphaZ1 (Gene Name=glra1)

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