Structure of PDB 6plf Chain A

Receptor sequence
>6plfA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
NLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVR
SATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSL
SAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLG
RIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFIT
VHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQC
AGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFV
DMVKG
3D structure
PDB6plf Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
1.1.1.399: 2-oxoglutarate reductase.
1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ONV A Y174 D175 P176 L193 H206 T207 P208 L216 Y170 D171 P172 L189 H202 T203 P204 L212 MOAD: ic50=0.238uM
PDBbind-CN: -logKd/Ki=6.67,Ki=214nM
BindingDB: IC50=238nM,Ki=214nM
Gene Ontology
Molecular Function
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:6plf, PDBe:6plf, PDBj:6plf
PDBsum6plf
PubMed31327531
UniProtO43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase (Gene Name=PHGDH)

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