Structure of PDB 6pl3 Chain A

Receptor sequence
>6pl3A (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
ACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKES
ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATR
NCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKF
TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPP
EVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL
3D structure
PDB6pl3 Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA).
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D650 R654 N655 D668
Catalytic site (residue number reindexed from 1) D146 R150 N151 D164
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OOD A A542 E560 L564 F589 H648 L657 G667 D668 F669 A43 E60 L64 F89 H144 L153 G163 D164 F165 PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
BindingDB: IC50=3.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pl3, PDBe:6pl3, PDBj:6pl3
PDBsum6pl3
PubMed31444087
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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