Structure of PDB 6pjv Chain A

Receptor sequence
>6pjvA (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERFKELTPNYNPDIIFKD
EENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEES
LHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAE
NS
3D structure
PDB6pjv Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design.
ChainA
Resolution1.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E90 E126 E52 E88
BS02 ZN A H140 D147 E176 H182 H102 D109 E138 H144
BS03 MG A H140 D147 E176 H182 H102 D109 E138 H144
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:6pjv, PDBe:6pjv, PDBj:6pjv
PDBsum6pjv
PubMed31692471
UniProtQ15465|SHH_HUMAN Sonic hedgehog protein (Gene Name=SHH)

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