Structure of PDB 6piu Chain A

Receptor sequence
>6piuA (length=197) [Search protein sequence]
MASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGE
VQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDL
VGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPI
SYLKGSSGGPLLCPAGHAVGIFRAAVSTRGVAKAVAFIPVESLETTM
3D structure
PDB6piu Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 H1149 C115 C117 C163 H167
BS02 OL7 A Q1041 Y1056 H1057 V1078 D1081 R1123 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 S1159 Q59 Y74 H75 V96 D99 R141 L153 K154 G155 S157 F172 R173 A174 A175 S177 MOAD: Ki=9.68nM
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019062 virion attachment to host cell
GO:0019087 transformation of host cell by virus
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6piu, PDBe:6piu, PDBj:6piu
PDBsum6piu
PubMed32234812
UniProtA0A0B4WYC6

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